DMSO

99.6% Purity

DMSO reduces inflammation by several mechanisms. It is an antioxidant, a scavenger of the free radicals that gather at the site of injury. This capability has been observed in experiments with laboratory animals7 and in 150 ulcerative colitis patients in a double-blinded randomized study in Baghdad, Iraq.8 DMSO also stabilizes membranes and slows or stops leakage from injured cells.

At the Cleveland Clinic Foundation in Cleveland, Ohio, in 1978, 213 patients with inflammatory genitourinary disorders were studied. Researchers concluded that DMSO brought significant relief to the majority of patients. They recommended the drug for all inflammatory conditions not caused by infection or tumor in which symptoms were severe or patients failed to respond to conventional therapy.9

Stephen Edelson, MD, F.A.A.F.P., F.A.A.E.M., who practices medicine at the Environmental and Preventive Health Center of Atlanta, has used DMSO extensively for 4 years. "We use it intravenously as well as locally," he says. "We use it for all sorts of inflammatory conditions, from people with rheumatoid arthritis to people with chronic low back inflammatory-type symptoms, silicon immune toxicity syndromes, any kind of autoimmune process.

"DMSO is not a cure," he continues. "It is a symptomatic approach used while you try to figure out why the individual has the process going on. When patients come in with rheumatoid arthritis, we put them on IV DMSO, maybe three times a week, while we are evaluating the causes of the disease, and it is amazing how free they get. It really is a dramatic treatment."

As for side effects, Dr. Edelson says: "Occasionally, a patient will develop a headache from it, when used intravenously--and it is dose related." He continues: "If you give a large dose, [the patient] will get a headache. And we use large doses. I have used as much as 30ml IV over a couple of hours. The odor is a problem. Some men have to move out of the room [shared] with their wives and into separate bedrooms. That is basically the only problem."

DMSO was the first nonsteroidal anti-inflammatory discovered since aspirin. Mr. Bristol believes that it was that discovery that spurred pharmaceutical companies on to the development on other varieties of nonsteroidal anti-inflammatories. "Pharmaceutical companies were saying that if DMSO can do this, so can other compounds," says Mr. Bristol. "The shame is that DMSO is less toxic and has less in the way of side effects than any of them

Published articles on DMSO have show benefit in the following entities:
  • Interstitial Cystitis
  • Scleroderma
  • Raynaud's Phenomenon
  • Lupus
  • Rheumatoid Arthritis
  • Degenerative Arthritis
  • Ulcerative Colitis
  • Chronic Obstructive Pulmonary Disease
  • Reflex Sympathetic Dystrophy
  • Diabetic Ulcerations
  • Burns
  • Scar Tissue
  • Adjunct in Plastic Surgery

Structured water and DMSO at http://www.dmso.org/articles/information/szmant.html

Eight years ago The New York Academy of Sciences sponsored a conference on the subject of forms of water in biological systcms,5 and the structure of water, the changes induced in its structure by the presence of different solutes, and the biological implications of the different states of water were of great concern to the participants. The evidence presented here suggests that DMSO stabilizes ice-like water clusters, and that it may therefore be capable of displacing the equilibrium between the less and more highly structured water, in favor of the latter. Since the hydration of cell constituents and the activity of water in general are not necessarily the same in the different states of water, it follows that DMSO may exert an indirect effect on biological systems by virtue of the changes that it causes in the liquid structure of water. Among the more important biological consequences of this indirect effect of DMSO, one can mention changes in the conformations and associations of proteins and other molecules. More direct biological effects caused by DMSO, without a profound change in its chemical identity, may include changes in ion-pairing equilibria and in the specific solvation of hydrogen-bond donors.

REFERENCES

  1. Tokuhiro, T., L, Memefra &, H. H. Szmant. 1974. J. Chem. Phys. In press.
  2. Eisenberg, D. & W. Kauzmann. 1969. The Structure and Properties of Water. Oxford University Press, Inc. New York, N.Y.
  3. Szmant, H. H. 1971. In Dimethyl Sulfoxide. S. W. Jacob, E. E. Rosenbaum & D. C. Wood, Eds. Marcel Dekker Inc. New York, N.Y.
  4. Rasmussen, D. H. & A. P. MacKenzie. 1968. Nature 220: 1315.
  5. Whipple, H. E., Ed. 1965. Ann. N.Y. Acad. Sci. 125(2): 249.

Links:

 

References

  1. Kolb, K.H., Jaenicke, G., Kramer, M., Schulze, P.E. Absorption, distribution, and elimination of labeled dimethyl sulfoxide in man and animals. Ann NY Acad Sci 141:85-95, 1967.
  2. Herschler, R., Jacob, S.W. The case of dimethyl sulfoxide. In: Lasagna, L. (Ed.), Controversies in Therapeutics. Philadelphia: W.B. Saunders, 1980.
  3. Evans, M.S., Reid, K.H., Sharp, J.B. Dimethyl sulfoxide (DMSO) blocks conduction in peripheral nerve C fibers: A possible mechanism of analgesia. Neurosci Lett 150:145-148, 1993.
  4. Demos, C.H., Beckloff, G.L., Donin, M.N., Oliver, P.M. Dimethyl sulfoxide in musculoskeletal disorders. Ann NY Acad Sci 141:517-523, 1967.
  5. Lockie, L.M., Norcross, B. A clinical study on the effects of dimethyl sulfoxide in 103 patients with acute and chronic musculoskeletal injures and inflammation. Ann NY Acad Sci 141:599-602, 1967.
  6. Percy, E.C., Carson, J.D. The use of DMSO in tennis elbow and rotator cuff tendinitis: A double-blind study. Med Sci Sports Exercise 13:215-219, 1981.
  7. Itoh, M., Guth, P. Role of oxygen-derived free radicals in hemorrhagic shock-induced gastric lesions in the rat. Gastroenterology 88:1126-1167, 1985.
  8. Salim, A.S., Role of oxygen-derived free radical scavengers in the management of recurrent attacks of ulcerative colitis: A new approach. J. Lab Clin Med 119:740-747, 1992.
  9. Shirley, S.W., Stewart, B.H., Mirelman, S. Dimethyl sulfoxide in treatment of inflammatory genitourinary disorders. Urology 11:215-220, 1978.
  10. Scherbel, A.L., McCormack, L.J., Layle, J.K. Further observations on the effect of dimethyl sulfoxide in patients with generalized scleroderma (progressive systemic sclerosis). Ann NY Acad Sci 141:613-629, 1967.
  11. Engel, M.F., Dimethyl sulfoxide in the treatment of scleroderma. South Med J 65:71, 1972.
  12. Sobel, D., Klein, A.C. Arthritis: What Works. New York: St. Martins Press, 1989.
  13. Santos, L., Tipping, P.G. Attenuation of adjuvant arthritis in rats by treatment with oxygen radical scavengers. Immunol Cell Biol 72:406-414, 1994.
  14. Matsumoto, J. Clinical trials of dimethyl sulfoxide in rheumatoid arthritis patients in Japan. Ann NY Acad Sci 141:560-568, 1967.
  15. de la Torre, J.C., et al. Modifications of experimental spinal cord injuries using dimethyl sulfoxide. Trans Am Neurol Assoc 97:230, 1971.
  16. de la Torre, J.C., et al. Dimethyl sulfoxide in the treatment of experimental brain compression. J Neurosurg 38:343, 1972.
  17. de la Torre, J.C., et al. Dimethyl sulfoxide in the central nervous system trauma. Ann NY Acad Sci 243:362, 1975.
  18. Lawrence, H.H., Goodnight, S.H. Dimethyl sulfoxide and extravasion of anthracycline agents. Ann Inter Med 98:1025, 1983.
  19. Lubredo, L., Barrie, M.S., Woltering, E.A. DMSO protects against adriamycin-induced skin necrosis. J. Surg Res 53:62-65, 1992.
  20. Alberts, D.S., Dorr, R.T. Case report: Topical DMSO for mitomycin-C-induced skin ulceration. Oncol Nurs Forum 18:693-695, 1991.
  21. Cruse, C.W., Daniels, S. Minor burns: Treatment using a new drug deliver system with silver sulfadiazine. South Med J 82:1135-1137, 1989.
  22. Miller, L., Hansbrough, J., Slater, H., et al. Sildimac: A new deliver system for silver sulfadiazine in the treatment of full-thickness burn injuries. J Burn Care Rehab 11:35-41, 1990
  23. Salim, A. Removing oxygen-derived free radicals delays hepatic metastases and prolongs survival in colonic cancer. Oncology 49:58-62, 1992.
  24. Feldman, W.E., Punch, J.D., Holden, P. In vivo and in vitro effects of dimethyl sulfoxide on streptomycin-sensitive and resistant Escherichia coli. Ann Acad Sci 141:231, 1967.
  25. Bentel JM, et al. Enhanced invasiveness and metastatic potential of epithelial cell lines cultured in the presence of dimethyl sulphoxide. International Journal of Cancer 1990;46:251-257.
  26. CA (Anonymous). Unproven methods of cancer management: dimethyl sulfoxide (DMSO). CA: a Cancer Journal for Clinicians 1983;33(2):122-125.
  27. Cassileth BR. Alternative medicine handbook: the complete reference guide to alternative and complementary therapies. New York: W.W. Norton & Co., 1998:161.
  28. Consumer Reports (Anonymous). Foods, drugs, or frauds? Consumer Reports 1985 May:275-279.
  29. Diamond WJ, et al. An alternative medicine definitive guide to cancer. Tiburon: Future Medicine Publishing, Inc., 1997:111,866-67.
  30. Dunlop M. Understanding cancer: an invaluable book for cancer patients and their families. Toronto: Irwin, 1985:108-110.
  31. Grunt THW, et al. Comparative analysis of the effects of dimethyl sulfoxide and retinoic acid on the antigenic pattern of human ovarian adenocarcinoma cells. Journal of Cell Science 1992;103:501-509.
  32. Hafner AW, editor. Reader's guide to alternative health methods. Milwaukee, Wisconsin: American Medical Association, 1993:296-299.
  33. Maehara M, et al. Dimethyl sulfoxide (DMSO) increases expression of sialyl Lewis x antigen and enhances adhesion of human gastric carcinoma (NUGC4) cells to activated endothelial cells. International Journal of Cancer 1993;54:296-301.
  34. Ontario Breast Cancer Information Exchange Project. Guide to unconventional cancer therapies. 1st ed. Toronto: Ontario Breast Cancer Information Exchange Project, 1994:271-274.
  35. Salim AS. The permissive role of oxygen-derived free radicals in the development of colonic cancer in the rat: a new theory for carcinogenesis. International Journal of Cancer 1993;53:1031-1035.
  36. Sorbye H, Kvinnsland S, Svanes K. Penetration of N-methyl-N'-nitro-N-nitrosoguanidine to proliferative cells in gastric mucosa of rats is different in pylorus and fundus and depends on exposure time and solvent. Carcinogenesis 1993;14(5):887-892.

To obtain 99.6% pure undiluted DMSO send us an e-mail

Price: 2 oz (60ml)  $30US, 1 litre $800 US

Booklet: DMSO : Nature's Healer, How to use DMSO to relieve pain, increase circulation, repair tissue damage and fight degenerative diseases" 340 pages,  by Morton Walker Price $20 US

 

Disclaimer: The information conveyed here is based on records and research for your information which is for horticultural, educational, sacramental and research purposes only.  No statement should be taken as medical advice.  It is not claimed or implied here that Mono-atomic SILVER-MAX or Colloidal mineral waters will cure any disease.

Contact:   Biophysica Inc., Toronto, Ont, Canada M6R 1S5 Phone: (905) 827-9448 (10am to 10pm EST)

e-mail: info@biophysica.com

Copyright 2001, Biophysica Inc. All rights reserved. Powered by Stonix.com.     

This page last updated on August 21, 2006 

Back to Home Page