1.  What about Herpes?
Herpes Simplex Virus (HSV) exists in two forms: HSV-1 and HSV-2. Either virus can infect the mouth or genitals but HSV–1 most commonly causes cold sores around the mouth and HSV–2 causes genital herpes. To realize how common they are; four out of five adults have HSV–1 and one in five has HSV–2.  Many don't know it because they do not have an active phase with blisters or sores.
Most of the time HSV is inactive staying in a nerve root at the base of the spine where it does no harm. In the active phase, it travels along the nerve to the skin where it causes irritation, bumps, blisters or sores which then shed virus out to the environment and other people. A major precipitating factors for an outbreak is depression accompanied by stress. The Centre for Disease Control reports that the incidence of Herpes has risen in the last ten years from 16% to 21%. This means that one in five are infected.
        Like many other viruses, the herpes virus has the ability to conceal itself inside the body's cells and to take over the cell's ability to replicate itself. The cell then replicates new virus. Drugs like Acyclovir act at the cellular level, prevent it from replicating and don't actually kill the herpes virus. As such they are not a "cure" but do provide considerable help in managing aspects of the disease such as passing it on and relief from symptoms.
A related virus is the Human Papilloma Virus (HPV) which is responsible for the highly infectious genital and peri-anal warts and associated with cancer of the cervix. It is the most common virally transmitted sexual disease causing warts in 1.4 million and sub-clinically infecting an estimated 100 million people. (World Congress of Dermatology, Sydney Australia, Oct, 1997,  Koutsky L.A., Amer. J. Med. 1997; 102,

Three-Dimensional Structure of Herpes Simplex Virus from Cryo-Electron Tomography

Herpes simplex virus, a DNA virus of high complexity, consists of a nucleocapsid surrounded by the tegument—a protein compartment—and the envelope. The latter components, essential for infectivity, are pleiomorphic. Visualized in cryo–electron tomograms of isolated virions, the tegument was seen to form an asymmetric cap: On one side, the capsid closely approached the envelope; on the other side, they were separated by 35 nanometers of tegument. The tegument substructure was particulate, with some short actin-like filaments. The envelope contained 600 to 750 glycoprotein spikes that varied in length, spacing, and in the angles at which they emerge from the membrane. Their distribution was nonrandom, suggesting functional clustering.

¹ Laboratory of Structural Biology, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
² Department of Pharmacology and Molecular Sciences, Johns Hopkins University, Baltimore, MD 21205, USA.
³ Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA.
⁴ Department of Molecular Structural Biology, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany.

From "Science" at  http://www.sciencemag.org/cgi/content/abstract/302/5649/1396

^* To whom correspondence should be addressed. E-mail: Alasdair_Steven@nih.gov

The above indicates that this virus is extremely evolved, complex and compact (in the low nanometre range).  It follows that an antiviral with particles or molecules in the low nanometre range such as well made Colloidal Silver would likely be more effective.

Links:

"Experts Voice New Alarm On Herpes: Many doctors are now recommending suppressive therapy -- the long-term daily use of an antiviral -- to prevent outbreaks and reduce the likelihood of transmission".

 By David Tuller  at http://www.nytimes.com/ads/c2c/sexhealth/article_J.html